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Aspirin for metal stent in malignant distal common bile duct obstruction (AIMS): study protocol for a multicenter randomized controlled trial

BACKGROUND: Endoscopic retrograde biliary drainage (ERBD) is the treatment of choice for patients with malignant distal common bile duct (CBD) obstruction. Self-expandable metal stents (SEMS), which are commonly used in unresectable cases, have many clinical advantages, including longer stent patency. Although the expected patency of SEMS is around 8 months, it has recently been reported that the duration of SEMS’ patency in patients using aspirin is prolonged. Our study, therefore, aims to…

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Background: Endoscopic retrograde biliary drainage (ERBD) is the treatment of choice for patients with malignant distal common bile duct (CBD) obstruction. Self-expandable metal stents (SEMS), which are commonly used in unresectable cases, have many clinical advantages, including longer stent patency. Although the expected patency of SEMS is around 8 months, it has recently been reported that the duration of SEMS’ patency in patients using aspirin is prolonged. Our study, therefore, aims to investigate the effect of aspirin on SEMS’ patency.

Methods/design: This is an investigator-initiated, prospective, multicenter, double-blind, randomized placebo-controlled trial that will be conducted from November 2017 in four tertiary centers in South Korea. We intend to include in our study 184 adult (aged ≥ 20 years) patients with malignant distal CBD obstruction for whom ERBD with SEMS was successfully performed. The patients will be randomly allocated to two groups, which will comprise patients who have either taken 100 mg aspirin or a placebo for 6 months after index ERBD. The primary outcome will be the rate of stent dysfunction, and the secondary outcomes will be the duration of patency, the rate of reintervention, and the occurrence of adverse events.

Discussion: The aspirin for metal stents in malignant distal common bile duct obstruction (AIMS) study should determine the efficacy of aspirin in maintaining metal-stent patency in patients with malignant distal CBD obstructive.

Trial registration: ClinicalTrials.gov, ID: NCT03279809. Registered on 5 September 2017.

Keywords: Aspirin; Endoscopic retrograde cholangiopancreatography; Randomized controlled trial; Self-expandable metallic stents.

Source: https://pubmed.ncbi.nlm.nih.gov/32000828/?utm_source=no_user_agent&utm_medium=rss&utm_campaign=pubmed-2&utm_content=1TQbL92JdzYTve0m3OsSoggMby2JyZDVBLRHiDMYZkT1hs6YNQ&fc=20200804223051&ff=20201119183327&v=2.13.0

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What kind of pod systems can you use with cbd?

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Hey, I’ve recently started using cbd gummy’s to help with my anxiety attacks, but I’ve noticed it doesn’t take effect fast enough to really help. I want to try out vaping it but I am not really interested in using disposables. Can you use any kind of pod systems to vape eliquid?

Source: https://www.reddit.com/r/CBD/comments/l49kgi/what_kind_of_pod_systems_can_you_use_with_cbd/

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pre-made tincture are more expensive?

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I’ve been looking around for tinctures, mainly full spectrum 1000mg/30 mL. The price for this has been hovering around $60-$70 from several vendors. However as I was browsing through powders, I found 1000mg full spectrum powder for just $30 at cbdistillery, at half the cost of pre-made full spectrum tincture. Is the price difference mainly just convenience? Pre-made tinctures seem to be far more expensive than a DIY. I understand you’d need to buy a carrier oil to make a tincture, so the total cost at first purchase would be more than $30, but one would be set for making additional cbd tinctures in the future.

Source: https://www.reddit.com/r/CBD/comments/l49ga2/premade_tincture_are_more_expensive/

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Have you guys noticed any synergetic effect of drinking coffe after/before taking cbd?

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Visit our community site for vetted suppliers at http://theCBD.place. It’s time that this subject was given more internet exposure. We are here to discuss topics related to medical marijuana and our experiences using CBD. Please do not assume that anyone here is a medical professional.

Source: https://www.reddit.com/r/CBD/comments/l4749q/have_you_guys_noticed_any_synergetic_effect_of/

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