Connect with us

Heartland

Anti-inflammatory Properties of Cannabidiol, a Nonpsychotropic Cannabinoid, in Experimental Allergic Contact Dermatitis

Phytocannabinoids modulate inflammatory responses by regulating the production of cytokines in several experimental models of inflammation. Cannabinoid type-2 (CB(2)) receptor activation was shown to reduce the production of the monocyte chemotactic protein-2 (MCP-2) chemokine in polyinosinic-polycytidylic acid [poly-(I:C)]-stimulated human keratinocyte (HaCaT) cells, an in vitro model of allergic contact dermatitis (ACD). We investigated if nonpsychotropic cannabinoids, such as cannabidiol…

Republished by Plato

Published

on

Phytocannabinoids modulate inflammatory responses by regulating the production of cytokines in several experimental models of inflammation. Cannabinoid type-2 (CB2) receptor activation was shown to reduce the production of the monocyte chemotactic protein-2 (MCP-2) chemokine in polyinosinic-polycytidylic acid [poly-(I:C)]-stimulated human keratinocyte (HaCaT) cells, an in vitro model of allergic contact dermatitis (ACD). We investigated if nonpsychotropic cannabinoids, such as cannabidiol (CBD), produced similar effects in this experimental model of ACD. HaCaT cells were stimulated with poly-(I:C), and the release of chemokines and cytokines was measured in the presence of CBD or other phytocannabinoids (such as cannabidiol acid, cannabidivarin, cannabidivarinic acid, cannabichromene, cannabigerol, cannabigerolic acid, cannabigevarin, tetrahydrocannabivarin, and tetrahydrocannabivarinic acid) and antagonists of CB1, CB2, or transient receptor potential vanilloid type-1 (TRPV1) receptors. HaCaT cell viability following phytocannabinoid treatment was also measured. The cellular levels of endocannabinoids [anandamide (AEA), 2-arachidonoylglycerol] and related molecules (palmitoylethanolamide, oleoylethanolamide) were quantified in poly-(I:C)-stimulated HaCaT cells treated with CBD. We show that in poly-(I:C)-stimulated HaCaT cells, CBD elevates the levels of AEA and dose-dependently inhibits poly-(I:C)-induced release of MCP-2, interleukin-6 (IL-6), IL-8, and tumor necrosis factor-α in a manner reversed by CB2 and TRPV1 antagonists 6-iodopravadoline (AM630) and 5′-iodio-resiniferatoxin (I-RTX), respectively, with no cytotoxic effect. This is the first demonstration of the anti-inflammatory properties of CBD in an experimental model of ACD.

Source: https://pubmed.ncbi.nlm.nih.gov/29632236/?utm_source=no_user_agent&utm_medium=rss&utm_campaign=pubmed-2&utm_content=1TQbL92JdzYTve0m3OsSoggMby2JyZDVBLRHiDMYZkT1hs6YNQ&fc=20200804223051&ff=20200817033756&v=2.11.5

Heartland

Placed an order with Plain Jane, didn’t receive order confirmation email.

Republished by Plato

Published

on

Hey guys, just want to hear from some people who have ordered from them before and know if thats normal or not. This is my first time ordering from them, I took a screenshot when I checked out and it gave me my order number, I definitely put in the right email and stuff.

Usually most transactions online result in an instant email that notifies they got my order, I got nothing at all, just seems pretty weird and makes me a bit worried.

Is this normal?

Source: https://www.reddit.com/r/CBD/comments/ltugeb/placed_an_order_with_plain_jane_didnt_receive/

Continue Reading

Heartland

I Tried Tommy Chong's Good Vibes Protocol CBD & It Changed Everything

Republished by Plato

Published

on

Oils, pills, even gummy bears — and it didn't do a thing for me. I wasn't the only one. I asked friends of mine, and most of us had tried CBD before and … Source:

Continue Reading

Heartland

https://gayle-king-cbd-oil-review.medium.com/gayle-king-cbd-oil-real-reviews-and

Republished by Plato

Published

on

https://gayle-king-cbd-oil-review.medium.com/gayle-king-cbd-oil-real-reviews-and. Started by kaliertyiowe , Feb 27 2021 12:03 PM. Please log in to reply. Source:

Continue Reading
Heartland4 days ago

Explained: How CBD Oil is Different Than CBD Capsule?

Heartland4 days ago

MMJRecs 7 Things Drivers Need To Know About Carrying MMJ In Your Car

Heartland4 days ago

Uncategorized3 days ago

What CBD Oil is Right For Me?

Heartland2 days ago

Heartland3 days ago

Material5 days ago

Hall–Petch effect in binary and ternary alumina / zirconia / spinel composites

Metal4 days ago

Ex-Baltic scrap deal closed at $445/mt CFR in Turkey

Heartland4 days ago

4 days ago

Up, up and away!

Heartland4 days ago

It really works

Heartland4 days ago

What are Acidic Cannabinoids, and How Do They Work?

Heartland3 days ago

CBD Oil for Beginners

Heartland5 days ago

CBD Oil Market Size 2021 | Driving Factors by Manufacturers – ENDOCA, IRIE CBD, Aurora …

Material5 days ago

Decomposition mechanism of AlMgB14 during the spark plasma sintering

Metal3 days ago

Pakistani CRC and HDG producers raise prices on higher input costs

Heartland3 days ago

Registration opens for consumable hemp manufacturers and retailers

Heartland3 days ago

Heartland2 days ago

Material4 days ago

Enhanced energy storage properties of amorphous BiFeO3/Al2O3 multilayers

Automotive4 days ago

This Morning in Metals: US industrial production up 0.9% in January

Manufacturing4 days ago

Shift 5% of Workforce Training Funds to Advance Entrepreneurship

Heartland4 days ago

website for flower

Heartland4 days ago

Heartland4 days ago

Superior Vibes CBD Oil

Heartland3 days ago

Interactions between CBD and hormonal contraception

Heartland3 days ago

CBD Skincare Products Are Popping Up Everywhere — But Do They Actually Work?

Material3 days ago

IMC microstructure modification and mechanical reinforcement of Sn–Ag–Cu/Cu microelectronic joints through an advanced surface finish technique

Material3 days ago

A new approach of predicting dynamic recrystallization using directly a flow stress model and its application to medium Mn steel

Heartland3 days ago

Hemp Is Creating an EcoRevolution

Trending

A Cloud Nine Capital Entity Copyright © 2020 – All Rights Reserved Proudly Made in America