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Adolescent exposure to Δ9-tetrahydrocannabinol alters the transcriptional trajectory and dendritic architecture of prefrontal pyramidal neurons

Neuronal circuits within the prefrontal cortex (PFC) mediate higher cognitive functions and emotional regulation that are disrupted in psychiatric disorders. The PFC undergoes significant maturation during adolescence, a period when cannabis use in humans has been linked to subsequent vulnerability to psychiatric disorders such as addiction and schizophrenia. Here, we investigated in a rat model the effects of adolescent exposure to Δ⁹-tetrahydrocannabinol (THC), a psychoactive component of…

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Fig. 4

Effect of normal development and THC exposure on transcriptional landscape. ab Development in vehicle-treated animals a resulted in 797 differentially expressed genes, whereas development in THC-treated animals b resulted in 975. Genes differentially expressed in both contrasts are colored blue (similar direction) or red (opposite direction), whereas other colors correspond to the biological categories shown in c. c Genes differentially expressed by developmental THC, which minimally overlapped with those differentially expressed in VEH-treated animals c’, engaged biological processes related to development, chromatin organization, and metabolism, as well as pathways related to cytosolic and nucleolar components. d Representative genes from these pathways included Dstn (top, actin cytoskeleton), Bap1 (middle, chromatin organization), and Pacsin1 (bottom, developmental processes), whose differential expression were replicated using NanoString (indicated by vertical bars with RNA-seq data shown as vertical lines for comparison). e Epigenetic- and dendritic-related genes within the WGCNA green-yellow module were significantly co-expressed in the THC-treated animals (THC) insomuch that a subset of genes were positively correlated, whereas a majority were anticorrelated. This pattern of coordinated expression was, however, not observed in the vehicle-treated animals (VEH). e Differential expression of the epigenetic-related genes from the WGCNA green-yellow module. *P ≤ 0.05, relative THC at 24 h. Data shown as mean ± SEM

Source: https://pubmed.ncbi.nlm.nih.gov/30283037/?utm_source=no_user_agent&utm_medium=rss&utm_campaign=pubmed-2&utm_content=1z7zlNEMzQex5jriqkhCblNtckSEpT9xYlxxeymU_73UTETESY&fc=20200804213258&ff=20200810102726&v=2.11.5

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Reliable cbd websites in the US ? Im not sure who to trust for quality

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Visit our community site for vetted suppliers at http://theCBD.place. It’s time that this subject was given more internet exposure. We are here to discuss topics related to medical marijuana and our experiences using CBD. Please do not assume that anyone here is a medical professional.

Source: https://www.reddit.com/r/CBD/comments/ltazi4/reliable_cbd_websites_in_the_us_im_not_sure_who/

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Cannabis and the Autistic Spectrum

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Visit our community site for vetted suppliers at http://theCBD.place. It’s time that this subject was given more internet exposure. We are here to discuss topics related to medical marijuana and our experiences using CBD. Please do not assume that anyone here is a medical professional.

Source: https://www.reddit.com/r/CBD/comments/lta8xe/cannabis_and_the_autistic_spectrum/

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Is 0.5 grams too much for a beginner?

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I just bought my very first pre-rolls! I started taking gummies every now and then about 3 months ago to help with my anxiety and panic attacks but i hear smoking gives you the desired effect much quicker.

The package says each roll is 0.5 grams but that sounds like a lot to me. Can anyone give me some advice?

Source: https://www.reddit.com/r/CBD/comments/lt9tz2/is_05_grams_too_much_for_a_beginner/

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