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A prospective open-label trial of a CBD/THC cannabis oil in dravet syndrome

CONCLUSIONS: TIL-TC150 was safe and well tolerated in our subjects. TIL-TC150 treatment resulted in a reduction in seizure counts, spike index on EEG, and improved quality of life measures. This study provides safety and dosing information for THC-containing cannabinoid preparations.

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Introduction: Both Δ9 Tetrahydrocannabidiol (THC) and cannabidiol (CBD) components of cannabis, have been shown to have anticonvulsant effects. Cannabis oils are used to treat seizures in drug-resistant epilepsy (DRE). Recent trials provide data on dosing, side effects, and efficacy of CBD, yet there is a paucity of information on THC in epilepsy. Primary objective was to establish dosing and tolerability of TIL-TC150 – a cannabis plant extract produced by Tilray®, containing 100 mg/mL CBD and 2 mg/mL THC- in children with Dravet syndrome. Secondary objectives were to assess impact of therapy on seizures, electroencephalogram (EEG) and quality of life.

Methods: Twenty children received add-on therapy with TIL-TC150. The dose ranged from 2 to 16 mg/kg/day of CBD and 0.04 to 0.32 mg/kg/day of THC. Patients were monitored for tolerability and adverse events, and secondary objectives.

Results: Nineteen participants completed the 20-week intervention. Mean dose achieved was 13.3 mg/kg/day of CBD (range 7-16 mg/kg/day) and 0.27 mg/kg/day of THC (range 0.14-0.32 mg/kg/day). Adverse events, common during titration included somnolence, anorexia, and diarrhea. Abnormalities of liver transaminases and platelets were observed with concomitant valproic acid therapy. There was a statistically significant improvement in quality of life, reduction in EEG spike activity, and median motor seizure reduction of 70.6%, with 50% responder rate of 63%.

Conclusions: TIL-TC150 was safe and well tolerated in our subjects. TIL-TC150 treatment resulted in a reduction in seizure counts, spike index on EEG, and improved quality of life measures. This study provides safety and dosing information for THC-containing cannabinoid preparations.

Source: https://pubmed.ncbi.nlm.nih.gov/30250864/?utm_source=no_user_agent&utm_medium=rss&utm_campaign=pubmed-2&utm_content=1TUbR4JfRTv1rbahLd1HaiF0w5ryO5ocWB3_xk3Prq78L0AEhI&fc=20200804222312&ff=20200815235258&v=2.11.5

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Placed an order with Plain Jane, didn’t receive order confirmation email.

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Hey guys, just want to hear from some people who have ordered from them before and know if thats normal or not. This is my first time ordering from them, I took a screenshot when I checked out and it gave me my order number, I definitely put in the right email and stuff.

Usually most transactions online result in an instant email that notifies they got my order, I got nothing at all, just seems pretty weird and makes me a bit worried.

Is this normal?

Source: https://www.reddit.com/r/CBD/comments/ltugeb/placed_an_order_with_plain_jane_didnt_receive/

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I Tried Tommy Chong's Good Vibes Protocol CBD & It Changed Everything

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Oils, pills, even gummy bears — and it didn't do a thing for me. I wasn't the only one. I asked friends of mine, and most of us had tried CBD before and … Source:

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https://gayle-king-cbd-oil-review.medium.com/gayle-king-cbd-oil-real-reviews-and

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https://gayle-king-cbd-oil-review.medium.com/gayle-king-cbd-oil-real-reviews-and. Started by kaliertyiowe , Feb 27 2021 12:03 PM. Please log in to reply. Source:

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