Connect with us

Heartland

A Novel Self-Emulsifying Drug Delivery System (SEDDS) Based on VESIsorb® Formulation Technology Improving the Oral Bioavailability of Cannabidiol in Healthy Subjects

Cannabidiol (CBD), a phytocannabinoid compound of Cannabis sativa, shows limited oral bioavailability due to its lipophilicity and extensive first-pass metabolism. CBD is also known for its high intra- and inter-subject absorption variability in humans. To overcome these limitations a novel self-emulsifying drug delivery system (SEDDS) based on VESIsorb^(®) formulation technology incorporating CBD, as Hemp-Extract, was developed (SEDDS-CBD). The study objective was to evaluate the…

Republished by Plato

Published

on

Cannabidiol (CBD), a phytocannabinoid compound of Cannabis sativa, shows limited oral bioavailability due to its lipophilicity and extensive first-pass metabolism. CBD is also known for its high intra- and inter-subject absorption variability in humans. To overcome these limitations a novel self-emulsifying drug delivery system (SEDDS) based on VESIsorb® formulation technology incorporating CBD, as Hemp-Extract, was developed (SEDDS-CBD). The study objective was to evaluate the pharmacokinetic profile of SEDDS-CBD in a randomized, double-blind, cross-over design in 16 healthy volunteers under fasted conditions. As reference formulation, the same Hemp-Extract diluted with medium-chain triglycerides (MCT-CBD) was used. CBD dose was standardized to 25 mg. Pharmacokinetic parameters were analyzed from individual concentration-time curves. Single oral administration of SEDDS-CBD led to a 4.4-fold higher Cmax and a 2.85-/1.70-fold higher AUC0-8h/AUC0-24h compared to the reference formulation. Tmax was substantially shorter for SEDDS-CBD (1.0 h) compared to MCT-CBD (3.0 h). Subgroup analysis demonstrated a higher bioavailability in women compared to men. This difference was seen for MCT-CBD while SEDDS-CBD mitigated this gender effect. Overall, SEDDS-CBD showed a significant improvement for all determined pharmacokinetic parameters: increased CBD plasma values (Cmax), favorably enhanced bioavailability (AUC) and fast absorption (Tmax). No safety concerns were noted following either administration.

Keywords: CBD; Cannabis sativa; SEDDS; bioavailability; cannabidiol; hemp extract; human; oral drug delivery system; pharmacokinetic.

Source: https://pubmed.ncbi.nlm.nih.gov/31426272/?utm_source=no_user_agent&utm_medium=rss&utm_campaign=pubmed-2&utm_content=1LgINZmdEb7hTii13TOa5DGOR2cvkVQ2sw4N7-xSaEiod6ucE1&fc=20200804221722&ff=20200813025825&v=2.11.5

Heartland

Thinking about ordering some CBD online from a reputable source, but the lab results say it has .20% THC? Can I have this shipped?

Republished by Plato

Published

on

I’m in Michigan. Really want to try this but I’m worried about shipping it to my apartment and having it get seized or getting in trouble or something.

I want to put the link to the website but I’m not sure if I can source so I’ll just say the brand is pretty reputable I just don’t know if I could get in trouble for this and what the likelihood of that would be.

Like I said it’s CBD flower but it still has larger amounts of CBD unlike most CBD in Michigan which has .3% or less (legal limit.)

Anyone think I’d be fine to order it?

Source: https://www.reddit.com/r/CBD/comments/lsgs4p/thinking_about_ordering_some_cbd_online_from_a/

Continue Reading

Heartland

Lifter 💚 21.6% CBDa

Republished by Plato

Published

on

Visit our community site for vetted suppliers at http://theCBD.place. It’s time that this subject was given more internet exposure. We are here to discuss topics related to medical marijuana and our experiences using CBD. Please do not assume that anyone here is a medical professional.

Source: https://www.reddit.com/r/CBD/comments/lsgpsn/lifter_216_cbda/

Continue Reading

Heartland

I believe I was scammed by Peace CBD. Has anyone heard of this brand? HELP!

Republished by Plato

Published

on

Hi, thank you for your time!

My grandparents are avid CBD users, and always order from the same brand. Around 3 months ago they received a package with a bottle of Peace CBD oil in it which they had not ordered, but they had lots of family staying at their house for Christmas and thought it must have been an order placed by somebody else. But they received another in late January, and now they realized they have been charged $100 a month, all by different billing companies across the USA, and they believe it is for these bottles of CBD. They have obviously not opened or used them, and I have had little success tracking down any information about this company online. The only posts on Reddit I was able to find under “Peace CBD” all seemed weird and scam-like, and contained the following two weird scam-like links. I was hoping someone has heard of this company or a similar scam.

(My grandparents think these scammers could have possibly gotten their information from a CBD trial they had signed up for about a year ago when they were finding a brand of CBD they liked.)

Any help or information is much appreciated!

https://sites.google.com/view/peace-cbd-oil-benefits/

https://apnews.com/press-release/newmediawire/lifestyle-business-stress-anxiety-mental-health-95498ba8a73a4c10676ba086875744b5

This last link is what comes up if you click on the attached link to “Buy Peace CBD today” on the ap article. It is not even the actual bottle of peace cbd.

https://buycannagenix.com/m/index?ts=64AAF081&s1=2503&s2=4464-8958&clickid=167390707

Thank you so much!

Source: https://www.reddit.com/r/CBD/comments/lsg4si/i_believe_i_was_scammed_by_peace_cbd_has_anyone/

Continue Reading
Heartland3 days ago

Florida Bill Aims to Legalize Medical Magic Mushrooms

Heartland2 days ago

Explained: How CBD Oil is Different Than CBD Capsule?

Material4 days ago

Nanocrystallization of a Ti40 cladding layer by ultrasonic impact to improve burn resistance

Heartland3 days ago

Delta 8: Shipping Vape Ban Goes Into Effect Soon – What Does It Means?

Heartland4 days ago

Affordable cbd oil?

Metal3 days ago

Local Turkish DKP grade scrap prices remain stable

Material4 days ago

Investigation of severe lunar environmental conditions on the physical and mechanical properties of lunar regolith geopolymers

Material4 days ago

Wear behavior of nanostructured carbo-austempered cast steels under rolling-sliding conditions

Heartland4 days ago

Heartland5 days ago

Material4 days ago

Dielectric properties and potential applications of alizarin yellow GG-Cu(II) complex film blended with polyvinyl alcohol

Heartland4 days ago

CBD and Inflammation

Heartland3 days ago

Bermuda Prepares To Lock Horns With United Kingdom Over Adult Use Cannabis

Material3 days ago

Chemical attack and corrosion resistance of concrete prepared with electrolyzed water

Manufacturing5 days ago

Making a Yellow Taxi Toplight

Heartland5 days ago

Perfect harmony blended with an inked soul, Craig Cavanagh to create sensations in the mind

Manufacturing4 days ago

What can I use besides injection moulding?

Material4 days ago

A method for estimating superplastic material parameters via free–inflation tests

Material4 days ago

Growth kinetics of the FeB/Fe2B boride layer on the surface of 4Cr5MoSiV1 steel: experiments and modelling

Heartland4 days ago

Unnamed Company Tried to Buy Aphria While It Was Negotiating Tilray Merger

Material4 days ago

Influence of heavy metal oxides to the mechanical and radiation shielding properties of borate and silica glass system

Material3 days ago

Competitive mechanisms occurring during quenching and partitioning of three silicon variants of 0.4 wt.% carbon steels

Heartland3 days ago

Where To Buy CBD in Fort Worth

Material4 days ago

Electronic and magnetic properties of graphene quantum dots doped with alkali metals

News4 days ago

2:1 or 1:1 CBD to Delta-8 THC Ratio: You Decide!

Material4 days ago

Correlative cross-sectional characterization of nitrided, carburized and shot-peened steels: synchrotron micro-X-ray diffraction analysis of stress, microstructure and phase gradients

Material4 days ago

Activated carbon electrode with promising specific capacitance based on potassium bromide redox additive electrolyte for supercapacitor application

Material5 days ago

Fatigue rate evaluation of a transparent polyester resin subjected to low-temperature environments

Heartland4 days ago

Efficacy of CBD Edibles

Material5 days ago

Modeling analysis of the tensile strength of polypropylene base Short Carbon Fiber reinforced composites

Trending

A Cloud Nine Capital Entity Copyright © 2020 – All Rights Reserved Proudly Made in America