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A Novel Self-Emulsifying Drug Delivery System (SEDDS) Based on VESIsorb® Formulation Technology Improving the Oral Bioavailability of Cannabidiol in Healthy Subjects
Cannabidiol (CBD), a phytocannabinoid compound of Cannabis sativa, shows limited oral bioavailability due to its lipophilicity and extensive first-pass metabolism. CBD is also known for its high intra- and inter-subject absorption variability in humans. To overcome these limitations a novel self-emulsifying drug delivery system (SEDDS) based on VESIsorb^(®) formulation technology incorporating CBD, as Hemp-Extract, was developed (SEDDS-CBD). The study objective was to evaluate the…
Cannabidiol (CBD), a phytocannabinoid compound of Cannabis sativa, shows limited oral bioavailability due to its lipophilicity and extensive first-pass metabolism. CBD is also known for its high intra- and inter-subject absorption variability in humans. To overcome these limitations a novel self-emulsifying drug delivery system (SEDDS) based on VESIsorb® formulation technology incorporating CBD, as Hemp-Extract, was developed (SEDDS-CBD). The study objective was to evaluate the pharmacokinetic profile of SEDDS-CBD in a randomized, double-blind, cross-over design in 16 healthy volunteers under fasted conditions. As reference formulation, the same Hemp-Extract diluted with medium-chain triglycerides (MCT-CBD) was used. CBD dose was standardized to 25 mg. Pharmacokinetic parameters were analyzed from individual concentration-time curves. Single oral administration of SEDDS-CBD led to a 4.4-fold higher Cmax and a 2.85-/1.70-fold higher AUC0-8h/AUC0-24h compared to the reference formulation. Tmax was substantially shorter for SEDDS-CBD (1.0 h) compared to MCT-CBD (3.0 h). Subgroup analysis demonstrated a higher bioavailability in women compared to men. This difference was seen for MCT-CBD while SEDDS-CBD mitigated this gender effect. Overall, SEDDS-CBD showed a significant improvement for all determined pharmacokinetic parameters: increased CBD plasma values (Cmax), favorably enhanced bioavailability (AUC) and fast absorption (Tmax). No safety concerns were noted following either administration.
Keywords: CBD; Cannabis sativa; SEDDS; bioavailability; cannabidiol; hemp extract; human; oral drug delivery system; pharmacokinetic.
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Thinking about ordering some CBD online from a reputable source, but the lab results say it has .20% THC? Can I have this shipped?
I’m in Michigan. Really want to try this but I’m worried about shipping it to my apartment and having it get seized or getting in trouble or something.
I want to put the link to the website but I’m not sure if I can source so I’ll just say the brand is pretty reputable I just don’t know if I could get in trouble for this and what the likelihood of that would be.
Like I said it’s CBD flower but it still has larger amounts of CBD unlike most CBD in Michigan which has .3% or less (legal limit.)
Anyone think I’d be fine to order it?
Source: https://www.reddit.com/r/CBD/comments/lsgs4p/thinking_about_ordering_some_cbd_online_from_a/
Visit our community site for vetted suppliers at http://theCBD.place. It’s time that this subject was given more internet exposure. We are here to discuss topics related to medical marijuana and our experiences using CBD. Please do not assume that anyone here is a medical professional.
Source: https://www.reddit.com/r/CBD/comments/lsgpsn/lifter_216_cbda/
Hi, thank you for your time!
My grandparents are avid CBD users, and always order from the same brand. Around 3 months ago they received a package with a bottle of Peace CBD oil in it which they had not ordered, but they had lots of family staying at their house for Christmas and thought it must have been an order placed by somebody else. But they received another in late January, and now they realized they have been charged $100 a month, all by different billing companies across the USA, and they believe it is for these bottles of CBD. They have obviously not opened or used them, and I have had little success tracking down any information about this company online. The only posts on Reddit I was able to find under “Peace CBD” all seemed weird and scam-like, and contained the following two weird scam-like links. I was hoping someone has heard of this company or a similar scam.
(My grandparents think these scammers could have possibly gotten their information from a CBD trial they had signed up for about a year ago when they were finding a brand of CBD they liked.)
Any help or information is much appreciated!
https://sites.google.com/view/peace-cbd-oil-benefits/
This last link is what comes up if you click on the attached link to “Buy Peace CBD today” on the ap article. It is not even the actual bottle of peace cbd.
https://buycannagenix.com/m/index?ts=64AAF081&s1=2503&s2=4464-8958&clickid=167390707
Thank you so much!
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