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A myeloperoxidase-responsive and biodegradable luminescent material for real-time imaging of inflammatory diseases

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We report the synthesis and characterization of a myeloperoxidase (MPO)-responsive, biodegradable, and luminescent material derived from functionalized cyclodextrin. The nanoparticle based on this functional material shows notably high and sustainable luminescent signals upon triggering by inflammatory conditions with abnormally elevated reactive oxygen species and MPO. Activated neutrophils during inflammatory responses can be selectively imaged using this nanoprobe, with luminescent signals positively correlated to neutrophil counts. This nanoprobe enables in vivo precise quantification and tracking of the number and dynamics of neutrophils in both superficial and deep tissues in various mouse models of inflammatory diseases, including peritonitis, paw edema, colitis, and acute lung injury. In vitro and in vivo evaluations also demonstrate the safety and biocompatibility of this newly engineered material in its native and nanoparticle forms.

This paper is available as an Article in Press, corrected proof, and due for print in Materials Today.

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Sign up/ Log in to your free Materials Today account to download the full article.

We report the synthesis and characterization of a myeloperoxidase (MPO)-responsive, biodegradable, and luminescent material derived from functionalized cyclodextrin. The nanoparticle based on this functional material shows notably high and sustainable luminescent signals upon triggering by inflammatory conditions with abnormally elevated reactive oxygen species and MPO. Activated neutrophils during inflammatory responses can be selectively imaged using this nanoprobe, with luminescent signals positively correlated to neutrophil counts. This nanoprobe enables in vivo precise quantification and tracking of the number and dynamics of neutrophils in both superficial and deep tissues in various mouse models of inflammatory diseases, including peritonitis, paw edema, colitis, and acute lung injury. In vitro and in vivo evaluations also demonstrate the safety and biocompatibility of this newly engineered material in its native and nanoparticle forms.

This paper is available as an Article in Press, corrected proof, and due for print in Materials Today.

Source: https://www.materialstoday.com/biomaterials/features/myeloperoxidaseresponsive-biodegradable-lumines/

Metal

Brazilian HDG exports and domestic offers increase

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Information Provided By:

SteelOrbis Elektronik Pazaryeri A.Ş. (“SteelOrbis”)
19 Mayıs Mahallesi, Atatürk Caddesi
Şeref Yazgan İş Merkezi, No: 72, Kat: 7, D: 18
Kozyatağı – 34736
Istanbul, Turkey

Trade Registration Number : 541892
MERSİS Number : 0470048178400014
Customer Relations Officer : Sinem Alpkaya
Tel : +90 216 468 10 50
Fax : +90 216 386 41 08

This Information Form has been drawn up in order to provide information to the customer (“Customer”) who seeks a free trial on an electronic environment for the purpose of benefiting from the services offered by the SteelOrbis website at “www.steelorbis.com” prior to acceptance of the Membership Contract, and it allows the Customer to gain clear information on the terms and conditions of the membership to be established as well as to review the text of the Contract in question.

The following successive steps shall be taken in order to establish a free trial:

– The Customer selects the “Free Trial” option on the home page at https://www.steelorbis.com.
– The Customer provides all information requested in the “Free Trial Application” form displayed on the screen and confirms it.
– SteelOrbis sends an account activation e-mail to the e-mail address of the Customer provided in the application form.
– The Customer clicks on the activation link sent to his/her e-mail address and activates his/her account. The website Membership Contract is presented to the Customer during the account activation process.

Storage of the Membership Contract:

You can either save the Membership Contract on your computer or make print-outs of it for storage. The Membership Contract accepted and confirmed by the Customer is not kept by SteelOrbis. You can always get access to the standard Membership Contract displayed on the website. However, as amendments may be made to the standard Contract, it may include some variations in comparison with the text approved by you. Accordingly, it may not be possible for you to access on the website the text you originally approved.

Data entry errors:

The information you should provide for membership application and the fields you should fill in are indicated during each step of the operation. You are obliged to provide such information. If you leave the required fields blank, the system will issue a warning. Please fill in all necessary fields. Prior to the completion of the operation, all data entered by you in the previous step will be displayed once more. Please make sure that the information provided by you is accurate and complete before finally confirming the operation; any missing or incorrect information should be completed or corrected. Any amendment or correction on the information provided by you after the confirmation may be performed by means of website logins after the establishment of the membership.

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Source: https://www.steelorbis.com/steel-prices/steel-prices-market-analyses/flats-and-slab/brazilian-hdg-exports-and-domestic-offers-increase-1174234.htm

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Metal

US tin plate exports up 19.4 percent in September

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According to export data from the US Department of Commerce, US exports of tin plate totaled 9,097 mt in September 2020, up 19.4 percent from August and up 45.3 percent from September 2019 levels. By value, tin plate exports totaled $5.9 million in September, compared to $5.2 million in the previous month and $4.7 million the same month last year.

The US shipped the most tin plate to Pakistan in September with 2,207 mt, compared to 1,201 mt in August and 516 mt in September 2019. Other top destinations included Mexico, with 1,265 mt; and Sri Lanka, with 1,000 mt.

Source: https://www.steelorbis.com/steel-news/latest-news/us-tin-plate-exports-up-194-percent-in-september-1174231.htm

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Metal

US tin plate exports up 19.4 percent in September

Republished by Plato

Published

on

According to export data from the US Department of Commerce, US exports of tin plate totaled 9,097 mt in September 2020, up 19.4 percent from August and up 45.3 percent from September 2019 levels. By value, tin plate exports totaled $5.9 million in September, compared to $5.2 million in the previous month and $4.7 million the same month last year.

The US shipped the most tin plate to Pakistan in September with 2,207 mt, compared to 1,201 mt in August and 516 mt in September 2019. Other top destinations included Mexico, with 1,265 mt; and Sri Lanka, with 1,000 mt.

Source: https://www.steelorbis.com/steel-news/latest-news/us-tin-plate-exports-up-194-percent-in-september-1174231.htm

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