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Δ-9-Tetrahydrocannabinol and Cannabidiol produce dissociable effects on prefrontal cortical executive function and regulation of affective behaviors

The use of cannabis for therapeutic and recreational purposes is growing exponentially. Nevertheless, substantial questions remain concerning the potential cognitive and affective side-effects associated with cannabis exposure. In particular, the effects of specific marijuana-derived phytocannabinoids on neural regions such as the prefrontal cortex (PFC) are of concern, given the role of the PFC in both executive cognitive function and affective processing. The main biologically active…

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The use of cannabis for therapeutic and recreational purposes is growing exponentially. Nevertheless, substantial questions remain concerning the potential cognitive and affective side-effects associated with cannabis exposure. In particular, the effects of specific marijuana-derived phytocannabinoids on neural regions such as the prefrontal cortex (PFC) are of concern, given the role of the PFC in both executive cognitive function and affective processing. The main biologically active phytocannabinoids, ∆-9-tetrahydrocannabinol (THC) and cannabidiol (CBD), interact with multiple neurotransmitter systems important for these processes directly within the PFC. Considerable evidence has demonstrated that acute or chronic THC exposure may induce psychotomimetic effects, whereas CBD has been shown to produce potentially therapeutic effects for both psychosis and/or anxiety-related symptoms. Using an integrative combination of cognitive and affective behavioral pharmacological assays in rats, we report that acute intra-PFC infusions of THC produce anxiogenic effects while producing no impairments in executive function. In contrast, acute infusions of intra-PFC CBD impaired attentional set-shifting and spatial working memory, without interfering with anxiety or sociability behaviors. In contrast, intra-PFC CBD reversed the cognitive impairments induced by acute glutamatergic antagonism within the PFC, and blocked the anxiogenic properties of THC, suggesting that the therapeutic properties of CBD within the PFC may be present only during pathologically aberrant states within the PFC. Interestingly, the effects of PFC THC vs. CBD were found to be mediated through dissociable CB1 vs. 5-HT1A-dependent receptor signaling mechanisms, directly in the PFC.

Source: https://pubmed.ncbi.nlm.nih.gov/30538288/?utm_source=no_user_agent&utm_medium=rss&utm_campaign=pubmed-2&utm_content=1LgINZmdEb7hTii13TOa5DGOR2cvkVQ2sw4N7-xSaEiod6ucE1&fc=20200804221722&ff=20200815071104&v=2.11.5

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What is one of the strongest CBD in vaping form?

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Visit our community site for vetted suppliers at http://theCBD.place. It’s time that this subject was given more internet exposure. We are here to discuss topics related to medical marijuana and our experiences using CBD. Please do not assume that anyone here is a medical professional.

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Source: https://www.reddit.com/r/CBD/comments/m0zvtg/what_is_one_of_the_strongest_cbd_in_vaping_form/

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Anzac Day march increased to 5000 in Sydney's CBD

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Any veteran who wishes to participate in the Sydney CBD march will be required to register via the RSL NSW website.

In previous years, veterans and their descendants have not been required to register to march, with more than 12,000 taking to Sydney’s streets in 2019.

Earlier on Tuesday, Mr Morrison said he would like to see Anzac Day celebrations “return to normal as much as we possibly can”.

“I respect ultimately these are calls that have got to be made by state governments, but I want Anzac Day on,” he told reporters in Sydney.

“If people can party, and if people can protest, then we can remember as a nation and honour our veterans on Anzac Day. And I would like to see that done as fully and as safely as possible.”

In 2020, Anzac Day marches across Australia were cancelled as the nation entered strict coronavirus restrictions. In lieu of the march, “Light Up the Dawn” driveway services were held in neighbourhoods across the country.

Tuesday marked NSW’s 51st consecutive day of no locally acquired coronavirus cases.

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Source: https://www.google.com/url?rct=j&sa=t&url=https://www.smh.com.au/national/nsw/anzac-day-march-increased-to-5000-in-sydney-s-cbd-20210309-p5792r.html&ct=ga&cd=CAIyGjQ2MzM1ZTBkNWQyZmIyYzc6Y29tOmVuOlVT&usg=AFQjCNGJKXeFEPybOePsWcm_wHfdMbTZww

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Anzac Day march increased to 5000 in Sydney's CBD

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The Anzac Day march in Sydney's CBD will be capped at 5000 after RSL NSW reached an agreement with the NSW government and police to … Checkout PrimeXBT
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